Serving Size 2 Capsules

烟酰胺核苷 (NR) 1000 毫克 — 肠溶衣包衣

Name: 烟酰胺核苷 (NR) 1000 毫克 — 肠溶包衣 60 片
Brand: Renue Store
SKU: 850055685109
Price: 402.0 CNY
Availability: InStock

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¥402.00 CNY

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NR 是人体用来产生 NAD+ 的天然分子。NR 1000 旨在提高 NAD+ 水平、优化细胞功能并促进整体健康和活力。

产品多属性

Serving Size 2 Capsules

NR 1000 Details

NAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. By providing Nicotinamide Riboside (NR), a direct precursor to NAD+, NR 1000™ helps boost the production of NAD+.†

“Together, this highlights that a multi-target strategy for NAD+ restoration such as the use of a precursor in combination with inhibitors and/or activators acting at other key points in the NAD+ network may be the optimum approach to NAD+ restoration.” (1)

NR is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for:

Energy production†DNA repair†Regulation of genes†Cellular health and vitality†Immune function†Regulation of the sleep-wake cycle†

Preventing NR Degradation is Essential

Research has shown that NAD+ precursors are largely degraded in the stomach and small intestine to other metabolites that are not as effective.

In a study, the fate of labeled NR was monitored in mice with and without gut bacteria following oral administration. The findings revealed a substantial breakdown of NR by gut bacteria into various metabolites, illustrated in the figure below.

The blue bars represent orally administered NR that has been labeled for detection. In regular mice (Reg NR), a portion of the labeled NR is converted into NAM, NA, and NAR in the colon’s lumen. However, in mice without gut microbiota (GF NR), the conversion of NR to NAM, NA, or NAR is reduced or completely halted, suggesting that gut microbiota plays a significant role in breaking down NR.

Safeguarding NR 1000 From Digestion in the Stomach

Several delivery systems have been developed to protect NAD+ precursors from being broken down and enhance their bioavailability (how much of a substance is absorbed into the bloodstream and can be used by the body).

In other products, we use advanced Liposomal technology, to protect NAD+ precursors from degradation in the GI tract and liver, but this delivery system adds significant cost.

Enteric Capsules Naturally Protect NR 1000™

NR 1000 provides 1000 mg of NR in enteric (acid resistant) capsules that protect the ingredients from harsh stomach acid and early breakdown by gut bacteria. The delayed release of NR ensures optimal absorption and efficiency.

The enteric capsules are naturally resistant to acid, meaning there is no need for harsh chemicals for maximum protection and enhanced stability:

Delayed release
Resistant to gastric acids and ultimately disintegrated in the small intestine
Low moisture content
Stability over a wide range of temperatures and humidity

查看完整详细信息

血液中的 NAD+ 水平由生产和消耗之间的微妙平衡决定。通过提供烟酰胺核糖 (NR)（NAD+ 的直接前体），NR 1000™ 有助于促进 NAD+ 的产生。†

“总之，这表明 NAD+ 恢复的多目标策略，例如使用前体与抑制剂和/或作用于 NAD+ 网络中其他关键点的激活剂相结合，可能是 NAD+ 恢复的最佳方法。”( 1 )

NR 是所有细胞中天然存在的分子。它是 NAD+ 的前体，NAD+ 是以下物质的重要分子：

能量生产†
DNA 修复†
基因调控†
细胞健康和活力†
免疫功能†
睡眠-觉醒周期的调节

防止天然橡胶降解至关重要

研究表明，NAD+前体在胃和小肠中大量降解为其他不太有效的代谢物。

在一项研究中，研究人员在有和没有肠道细菌的小鼠中监测了标记天然营养素口服后的命运。研究结果显示，肠道细菌会将天然营养素大量分解为各种代谢物。

在正常小鼠（Reg NR）中，一部分标记的 NR 在结肠腔中转化为 NAM、NA 和 NAR。然而，在缺乏肠道微生物群的小鼠（GF NR）中，NR 转化为 NAM、NA 或 NAR 的过程减少或完全停止，这表明肠道微生物群在分解 NR 方面发挥着重要作用。

保护 NR 1000 不被胃消化

已经开发出多种输送系统来保护 NAD+ 前体不被分解并提高其生物利用度（有多少物质被吸收进入血液并可被身体利用）。

在其他产品中，我们使用先进的脂质体技术来保护 NAD+ 前体免于在胃肠道和肝脏中降解，但这种输送系统增加了相当大的成本。

肠溶胶囊天然保护 NR 1000™

NR 1000 提供 1000 毫克 NR，采用肠溶（耐酸）胶囊包装，可保护成分免受胃酸侵蚀和肠道细菌早期分解。NR 的延迟释放可确保最佳吸收和效率。

肠溶胶囊天然耐酸，这意味着不需要使用刺激性化学品即可获得最大程度的保护和增强的稳定性：

延期发布
耐胃酸，最终在小肠中分解
低水分含量
在各种温度和湿度下均保持稳定

NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

肠溶胶囊保护NR

血液中的 NAD+ 水平由生产和消耗之间的微妙平衡决定。肠溶 NR 胶囊通过在不受胃酸性条件影响的胶囊中提供 NAD+ 的前体 NR，帮助促进 NAD+ 的产生。†

NAD+ 水平会随着年龄的增长而自然下降，研究表明这与与年龄相关的疾病的发生和发展有关。† 这使得提高 NAD+ 水平成为一个有希望的治疗目标。†

NMN 是 NAD+ 的前体，可作为强力的助推器来提升您的 NAD+ 水平。†

肠溶天然营养素胶囊旨在通过保护天然营养素免受消化酸性条件的影响而被肠道吸收，从而增强吸收率。†

哪种 NAD+ 前体最好？

NAD+

这种中心辅酶直接参与氧化还原反应，并作为能量产生酶活性的底物，包括 sirtuins 和聚（ADP-核糖）聚合酶 (PARPs)，它们调节细胞代谢、DNA 修复和表观遗传修饰。

纳米二核苷酸

这种 NAD+ 前体通过 Salvage 途径中的 NMNAT 酶直接转化为 NAD+，已被大量临床试验证明可以有效提高细胞内 NAD+ 水平，从而增强线粒体功能、能量产生和 NAD+ 依赖性酶的活性。

天然橡胶

这种 NAD+ 前体通过 Preiss-Handler 途径转化为 NAD+，还表现出提高细胞中 NAD+ 水平的能力。它支持细胞修复机制，特别是那些涉及 DNA 损伤反应和氧化应激缓解的机制。通过支持 NAD+ 水平，NR 促进 sirtuins 和 PARP 的激活，从而保护基因组稳定性并调节细胞代谢。

葫芦巴碱

葫芦巴碱促进细胞 NAD+ 生成的方式与 NMN 或 NR 不同。这种甲基化形式的烟酸具有多种优势：在血流中具有出色的稳定性、缓慢释放到目标组织中、不会引起潮红、防止胃消化以及直接增加肌肉组织中的 NAD+。

常见问题

How Do Enteric (Acid-Resistant) Capsules Work?

The enteric coated (acid-resistant) capsules are specifically designed to protect ingredients from the harsh acidic stomach, while safeguarding them from being degraded and digested by bacteria and enzymes.

The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract - with NAD+ precursors being particularly vulnerable to this.

The enteric (acid-resistant) capsules safeguard the ingredients to support better absorption, and a slower release into the bloodstream.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.