Recommended 2 Pumps

含 NAD⁺、NMN、NR、葫芦巴碱（脂质体）的鼻腔喷雾剂

Name: 含 NAD⁺、NMN、NR、葫芦巴碱（脂质体）的鼻腔喷雾剂
Brand: Renue Store
SKU: 850055685215
Price: 440.0 CNY
Availability: InStock

便捷的认知提升

¥440.00 CNY

结账时计算的运费。

如果您正在寻找方便携带的产品，我们的 NAD+ 鼻腔喷雾剂是您主要 NAD+ 补充剂的完美补充。

NAD+ 鼻喷雾剂提供针对性给药，专注于大脑，而不是广泛的全身循环。它旨在比所有其他给药方法对认知和脑雾产生更强的影响。†

产品多属性

Recommended 2 Pumps

Liposomal NAD+ Complete Nasal Spray

Support Cognition with our NAD⁺ Nasal Spray

If you’re looking for a convenient on-the-go product, our NAD+ nasal spray is the perfect complement to your main NAD+ supplements.

The spray provides targeted delivery, focusing on the brain, rather than widespread systemic circulation.

NAD+ nasal spray is designed to have a stronger effect on cognition and brain fog than all other delivery methods.† This spray is intended to enhance, not replace, your existing NAD+ supplementation.

Why Intranasal Delivery Is Highly Effective

Intranasal delivery is the one of the quickest and most effective ways to deliver NAD⁺ and its precursors, NMN and NR, into the body. The nasal mucosa’s rich blood flow allows for optimal drug absorption while avoiding the first-pass effect. (1)

The first pass effect refers to drugs getting metabolized at specification locations in the body, most often the liver, which results in the drug’s reduced concentration in systemic circulation or at the target site.

“Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs.” (2)

Improving NAD⁺ through Multiple Pathways

While there is a lot of uncertainty about the pathways NAD⁺ and NAD⁺ precursors take in the body, we do know that there are differences between them, and they have affinity for different tissues. We believe the most effective protocol to increase NAD⁺ is through targeting multiple pathways.

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NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

哪种 NAD+ 前体最好？

NAD+

这种中心辅酶直接参与氧化还原反应，并作为能量产生酶活性的底物，包括 sirtuins 和聚（ADP-核糖）聚合酶 (PARPs)，它们调节细胞代谢、DNA 修复和表观遗传修饰。

纳米二核苷酸

这种 NAD+ 前体通过 Salvage 途径中的 NMNAT 酶直接转化为 NAD+，已被大量临床试验证明可以有效提高细胞内 NAD+ 水平，从而增强线粒体功能、能量产生和 NAD+ 依赖性酶的活性。

天然橡胶

这种 NAD+ 前体通过 Preiss-Handler 途径转化为 NAD+，还表现出提高细胞中 NAD+ 水平的能力。它支持细胞修复机制，特别是那些涉及 DNA 损伤反应和氧化应激缓解的机制。通过支持 NAD+ 水平，NR 促进 sirtuins 和 PARP 的激活，从而保护基因组稳定性并调节细胞代谢。

葫芦巴碱

葫芦巴碱促进细胞 NAD+ 生成的方式与 NMN 或 NR 不同。这种甲基化形式的烟酸具有多种优势：在血流中具有出色的稳定性、缓慢释放到目标组织中、不会引起潮红、防止胃消化以及直接增加肌肉组织中的 NAD+。

提高生物利用度

脂质体递送

脂质体是一种革命性的方法，将活性成分封装在磷脂“气泡”中，以保护活性成分并将其直接输送到组织细胞，然后通过血液到达。（1）这样可以使成分被吸收和利用，而不会在胃中被破坏。

服用任何补充剂的目的是确保其进入血液。然而，由于传统口服胶囊的吸收率和生物利用度较低，活性成分在通过胃肠道时会失去大部分效力，或者根本无法在小肠中吸收。大多数未经利用就通过肠道或肾脏排出体外。（2）

脂质体递送可实现活性成分的定向和完全吸收，具有延迟释放效果，与所有其他营养递送方法不同。关键营养素在血液中的循环时间增加，显著提高了生物利用度。活性物质的生物利用度越高，其对身体的影响就越大。

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研究

脂质体提高生物利用度

使用我们的脂质体产品，无论有效载荷是什么，大约 90% 的有效载荷都能完整地到达血液。

例如，我们的脂质体绿茶提取物中约 90% 的 EGCG 能够到达血液。

通过常规绿茶提取物，约有9% 的 EGCG 会进入血液。

因此，下面的研究表明它的生物利用度大约高出 10 倍。

常规芹菜素的生物利用度约为 30% ，因此，您可以预期我们的脂质体芹菜素的生物利用度比常规芹菜素高出约 3 倍。

虽然我们没有对所有脂质体产品的生物利用度进行研究，但下面我们展示的研究表明，在我们生产的一些最受欢迎的补充剂中使用脂质体时，生物利用度提高了 3 到 40 倍。

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常见问题

When do LIPO gel products expire?

LIPO gel products are good for 2 years from the date of manufacture printed on the bottle.

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.