Nicotinamide adenine dinucleotide. NAD+ is essential for human health and is central to cellular metabolism, DNA repair, and many other essential operations. Over a century ago, its importance became clear when a deficiency in niacin, a precursor to NAD+, was linked to pellagra – a devastating disease characterized by dermatitis, diarrhea, dementia, and death. The diverse and severe symptoms of pellagra underscored just how crucial NAD+ is to the body’s basic functions.
Heather L. Makar is a biologist, longevity futurist, TEDx speaker, and science writer focused on translating complex mechanisms of aging into strategies for healthspan extension. At Renue By Science, she leads research-driven content strategy that empowers readers to understand, optimize, and evolve their own biology. She brings a multidisciplinary perspective to health optimization, bridging natural medicine and cutting edge science to build actionable protocols that have tangible effects immediately and far into the future.
September 29, 2025The Decision After reviewing robust records and relentless advocacy from the Natural Products Association, the FDA acknowledged what many of us already knew: NMN has been marketed rightfully...
Skin & Body Essentials is designed to fuel your body’s overnight repair cycle with a precise blend of: Glycine – Clinically shown to enhance sleep quality and promote deeper rest....
NMN, NR, and NAD+: A Brief Refresher NAD+ is an important molecule found in virtually every cell of your body, which is required for DNA repair, energy production, metabolism, and...
Key Points NMN outperformed NR and NAM, triggering stronger skin cell protection Cellular aging slowed through improved energy and repair activity Mitochondrial health and energy production were preserved Collagen production...
NMNH & NRH: Powerful But Complex Both NMNH and NRH are reduced forms of the more widely known counterparts. This structural difference means they enter the NAD+ pathway in a...
Once regarded as a simple coenzyme required for energy production, NAD⁺ is now recognized as a master regulator of health, supporting DNA repair, epigenetic programming, immune responses, and mitochondrial function....
