Nicotinamide Riboside (NR) is a natural building block for NAD+ production. LIPO NR is designed to elevate NAD+ levels, maintain cellular function, and enhance vitality and longevity.
NAD+ Is Essential to Life ...but declines with age
NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.
NAD+ Is Essential to Life ...but declines with age
NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.
Which NAD+ Precursor Is Best?
NAD+
This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.
NMN
This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.
NR
This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.
Trigonelline
Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.
Liposomal Delivery
Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream.⑴ This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.
The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵
Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body.
Liposomes Increase Bioavailability
With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.
For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.
With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.
Hence the study below shows it is about 10x more bioavailable.
Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin.
Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce.
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