葫芦巴碱（NAD+ 前体）-甲基化烟酸 250 毫克 90 粒

NAD+ 促进甲基化烟酸

¥377.00 CNY

结账时计算的运费。

葫芦巴碱促进细胞 NAD+ 产生的方式与其他前体（如 NMN 或 NR）不同。

这种甲基化形式的烟酸比其他形式的 B 族维生素具有优势：

血液中卓越的稳定性
缓慢释放至目标组织
非冲洗
防止胃消化
直接增加肌肉中的 NAD+（与 NMN 或 NR 不同）

产品多属性

Trigonelline Capsule

250mg Trigonelline

Details

This methylated form of Niacin has advantages over other forms of this B vitamin:

Exceptional stability in bloodstream
Slow release into target tissues
Non-flushing
Protected against digestion in the stomach
Increases NAD⁺ directly in muscle (unlike NMN or NR)

Trigonelline Details

Trigonelline (methylated niacin) is an NAD+ precursor that promotes NAD+ production in muscle cells, a property not observed in other NAD+ boosters like NMN or NR. It accomplishes this through conversion in the Preiss-Handler pathway, unlike other NAD+ precursors which utilize the Salvage pathway. Its innate bioavailable structure allows it to survive digestion, cross the blood-brain barrier, and directly stimulate NAD+ production in muscle, brain, and other tissues.

Trigonelline, as a methylated form of Niacin, actively promotes NAD+ restoration in muscle cells. While NMN and NR can increase NAD+ metabolites in muscle, there has been no evidence to indicate that either of these precursors actively increase NAD+ concentration in muscle, making Trigonelline the only precursor known to have this benefit.

Research shows that Trigonelline remains stable in circulation for more than 72 hours, compared to NR and NMN which are both rapidly degraded to NAM within only a few hours.

Consistent Trigonelline use can elevate NAD+ levels to support critical cellular functions including energy production, DNA repair, and cellular signaling:

Enhanced NAD+ Synthesis: Promotes NAD+ production via the Preiss-Handler pathway, essential for cellular energy and repair.
Cognitive Support: Crosses the blood-brain barrier, supporting cognitive function and protecting against age-related cognitive decline through protection of NAD+ stores in neurons.
Metabolic Regulation: Acts as a methyl donor in one-carbon metabolism, supporting methylation processes crucial for energy production and genetic expression.
Cardiovascular Health: Promotes the integrity of blood vessels and heart muscle, supporting endothelial function and circulatory health.
DNA Repair: Encourages cellular repair mechanisms and maintains DNA integrity, helping prevent mutations and supporting natural defenses against environmental stress.
Muscle Health: Protects against muscle loss and promotes muscle strength, crucial for maintaining physical fitness and metabolic health with aging.
Glucose and Lipid Management: Enhances insulin sensitivity and glucose uptake, stabilizing blood glucose levels. Modulates lipid metabolism by inhibiting lipogenic enzymes and promoting lipoprotein lipase activity, improving lipid profiles.

Trigonelline’s bioavailability and ability to cross the blood-brain barrier enable it to exert systemic benefits, supporting cognitive, cardiovascular, and metabolic health. It supports in glucose regulation by enhancing insulin receptor signaling and facilitates lipid management by influencing key enzymes in lipid metabolism.

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NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

葫芦巴碱（甲基化烟酸）是一种 NAD+ 前体，可促进肌肉细胞中 NAD+ 的产生，而其他 NAD+ 增强剂（如 NMN 或 NR）则不具备这种特性。它通过 Preiss-Handler 通路中的转化来实现这一目标，而其他 NAD+ 前体则利用 Salvage 通路。其先天的生物可利用结构使其能够经受住消化过程，穿过血脑屏障，并直接刺激肌肉、大脑和其他组织中 NAD+ 的产生。

葫芦巴碱是烟酸的甲基化形式，可积极促进肌肉细胞中的 NAD+ 恢复。虽然 NMN 和 NR 可以增加肌肉中的 NAD+ 代谢物，但没有证据表明这两种前体中的任何一种都能积极增加肌肉中的 NAD+ 浓度，因此葫芦巴碱是已知唯一具有此益处的前体。

研究表明，葫芦巴碱在循环中可以保持稳定超过 72 小时，而 NR 和 NMN 则在短短几个小时内迅速降解为 NAM。

持续使用葫芦巴碱可以提高 NAD+ 水平，以支持关键的细胞功能，包括能量产生、DNA 修复和细胞信号传导：

增强 NAD+ 合成：通过 Preiss-Handler 通路促进 NAD+ 的产生，这对细胞能量和修复至关重要。
认知支持：穿过血脑屏障，支持认知功能并通过保护神经元中的 NAD+ 储存来防止与年龄相关的认知衰退。
代谢调节：充当单碳代谢中的甲基供体，支持对能量产生和基因表达至关重要的甲基化过程。
心血管健康：促进血管和心肌的完整性，支持内皮功能和循环健康。
DNA 修复：促进细胞修复机制并维持 DNA 完整性，帮助防止突变并支持抵御环境压力的自然防御。
肌肉健康：防止肌肉流失并增强肌肉力量，这对于维持身体健康和衰老过程中的代谢健康至关重要。
葡萄糖和脂质管理：增强胰岛素敏感性和葡萄糖摄取，稳定血糖水平。通过抑制脂肪生成酶和促进脂蛋白脂肪酶活性来调节脂质代谢，改善脂质状况。

我们使用耐酸胶囊来容纳葫芦巴碱，以防止其被消化并促进肠道吸收，在肠道中，葫芦巴碱以较慢的速度被吸收以到达更多的组织。

葫芦巴碱的生物利用度和穿过血脑屏障的能力使其能够发挥全身益处，支持认知、心血管和代谢健康。它通过增强胰岛素受体信号传导来支持葡萄糖调节，并通过影响脂质代谢中的关键酶来促进脂质管理。

哪种 NAD+ 前体最好？

NAD+

这种中心辅酶直接参与氧化还原反应，并作为能量产生酶活性的底物，包括 sirtuins 和聚（ADP-核糖）聚合酶 (PARPs)，它们调节细胞代谢、DNA 修复和表观遗传修饰。

纳米二核苷酸

这种 NAD+ 前体通过 Salvage 途径中的 NMNAT 酶直接转化为 NAD+，已被大量临床试验证明可以有效提高细胞内 NAD+ 水平，从而增强线粒体功能、能量产生和 NAD+ 依赖性酶的活性。

天然橡胶

这种 NAD+ 前体通过 Preiss-Handler 途径转化为 NAD+，还表现出提高细胞中 NAD+ 水平的能力。它支持细胞修复机制，特别是那些涉及 DNA 损伤反应和氧化应激缓解的机制。通过支持 NAD+ 水平，NR 促进 sirtuins 和 PARP 的激活，从而保护基因组稳定性并调节细胞代谢。

葫芦巴碱

葫芦巴碱促进细胞 NAD+ 生成的方式与 NMN 或 NR 不同。这种甲基化形式的烟酸具有多种优势：在血流中具有出色的稳定性、缓慢释放到目标组织中、不会引起潮红、防止胃消化以及直接增加肌肉组织中的 NAD+。

常见问题

What are the benefits of Trigonelline?

HDSFIHISF P

How Trigonelline Works

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科学支持

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Strength and Purity Certification Gold Standard Testing Trigonelline Report

Dr. Recommended Methylated Niacin

After a recent functional blood test, my wellness Dr. recommended I take a quality Methylated Niacin. This seems to be doing the trick.

I love how the tracking number was there immediately. How this company made sure the package was secured in a parcel. I love the products.

Interesting supplement

On paper it's an interesting supplement. Does it do anything.., hard to say. I take most of the cutting edge supplements and have evolved my protocol over the last 25 years as the longevity sciences have advanced. I do take several NAD precursors as I'm convinced NAD is indicated in slowing aging. I also use several other advertised longevity supplements and Rapmyacin. I do look substantially younger than most 66 year olds. Outside a before and after DNA methylation measurent the only way to tell whether your routine works is to compare yourself generally with the populace and your twin sibling who never used the products. Those who take any longevity supplement and suddenly claim more energy, ect. are imagining it.

Of course, causality is impossible to identify in such instances, but for what it's worth, my taking this Trigonelline coincided with some positive health news about one important muscle.

Works great

I feel much better when I'm using it. More energy, better sleep.

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葫芦巴碱（NAD+ 前体）-甲基化烟酸 250 毫克 90 粒